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A condition caused by the defective metabolism of fat, causing a syndrome of insulin resistance, fat distribution (lipoatrophy) and blood fat abnormalities. Lipodystrophy is associated with the use of some older HIV ARV treatments, which are less used now for that reason. Lipodystrophy results in abnormal deposition of fat usually an accumulation around the stomach and sometime the upper back along with wasting of the face, limbs, and buttocks. This condition is now uncommon with newer HIV ARV treatments. There is a cosmetic dermal (under the skin) injectable facial treatment available for people living with HIV (PLHIV) to correct facial lipoatrophy, called Sculptra (poly lactic acid – PLA).